Clara L. Kielkopf : rechercher sur Z-Library

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1

Bradford Assay for Determining Protein Concentration

Kielkopf, Clara L., Bauer, William, Urbatsch, Ina L.

Journal:

Cold Spring Harbor Protocols

Année:

2020

Fichier:

PDF, 182 KB

2020

2

10.1038/72385

Barton, Jacqueline K., Rees, Douglas C., Kielkopf, Clara L., Erkkila, Kathryn E., Hudson, Brian P.

Journal:

Natural Structural Biology

Année:

2000

Langue:

english

Fichier:

PDF, 446 KB

english, 2000

3

Methods for Measuring the Concentrations of Proteins

Kielkopf, Clara L., Bauer, William, Urbatsch, Ina L.

Journal:

Cold Spring Harbor Protocols

Année:

2020

Fichier:

PDF, 262 KB

2020

4

Purification of Polyhistidine-Tagged Proteins by Immobilized Metal Affinity Chromatography

Kielkopf, Clara L., Bauer, William, Urbatsch, Ina L.

Journal:

Cold Spring Harbor Protocols

Année:

2020

Fichier:

PDF, 554 KB

2020

5

Major phosphorylation of SF1 on adjacent Ser-Pro motifs enhances interaction with U2AF65

Valérie Manceau, Matthew Swenson, Jean-Pierre Le Caer, André Sobel, Clara L. Kielkopf, Alexandre Maucuer

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 325 KB

english, 2006

6

Structural basis for G•C recognition in the DNA minor groove

Kielkopf, Clara L., Baird, Eldon E., Dervan, Peter B., Rees, Douglas C.

Journal:

Natural Structural Biology

Année:

1998

Fichier:

PDF, 1.72 MB

1998

7

X-Ray Structure of a Rex-Family Repressor/NADH Complex Insights into the Mechanism of Redox Sensing

E. Allen Sickmier, Dimitris Brekasis, Shanthi Paranawithana, Jeffrey B. Bonanno, Mark S.B. Paget, Stephen K. Burley, Clara L. Kielkopf

Journal:

Année:

2005

Langue:

english

Fichier:

PDF, 814 KB

english, 2005

8

Structural effects of DNA sequence on T·A recognition by hydroxypyrrole/pyrrole pairs in the minor groove

Clara L Kielkopf, Ryan E Bremer, Sarah White, Jason W Szewczyk, James M Turner, Eldon E Baird, Peter B Dervan, Douglas C Rees

Journal:

Journal of Molecular Biology

Année:

2000

Langue:

english

Fichier:

PDF, 459 KB

english, 2000

9

Conformational flexibility of B-DNA at 0.74 å resolution: d(CCAGTACTGG)2

Clara L Kielkopf, Sheng Ding, Peter Kuhn, Douglas C Rees

Journal:

Journal of Molecular Biology

Année:

2000

Langue:

english

Fichier:

PDF, 445 KB

english, 2000

10

Structure of the central RNA recognition motif of human TIA-1 at 1.95 Å resolution

Amit O. Kumar, Matthew C. Swenson, Matthew M. Benning, Clara L. Kielkopf

Journal:

Biochemical and Biophysical Research Communications

Année:

2008

Langue:

english

Fichier:

PDF, 1.64 MB

english, 2008

11

Multiple U2AF65 Binding Sites within SF3b155: Thermodynamic and Spectroscopic Characterization of Protein–Protein Interactions among pre-mRNA Splicing Factors

Karen R. Thickman, Matthew C. Swenson, Joseph M. Kabogo, Zygmunt Gryczynski, Clara L. Kielkopf

Journal:

Journal of Molecular Biology

Année:

2006

Langue:

english

Fichier:

PDF, 1.20 MB

english, 2006

12

Alternative Conformations at the RNA-binding Surface of the N-terminal U2AF65 RNA Recognition Motif

Karen R. Thickman, E. Allen Sickmier, Clara L. Kielkopf

Journal:

Journal of Molecular Biology

Année:

2007

Langue:

english

Fichier:

PDF, 924 KB

english, 2007

13

Different Requirements of the Kinase and UHM Domains of KIS for Its Nuclear Localization and Binding to Splicing Factors

Valérie Manceau, Clara L. Kielkopf, André Sobel, Alexandre Maucuer

Journal:

Journal of Molecular Biology

Année:

2008

Langue:

english

Fichier:

PDF, 1.32 MB

english, 2008

14

RNA Induces Conformational Changes in the SF1/U2AF65 Splicing Factor Complex

Ankit Gupta, Jermaine L. Jenkins, Clara L. Kielkopf

Journal:

Journal of Molecular Biology

Année:

2011

Langue:

english

Fichier:

PDF, 1.36 MB

english, 2011

15

Three RNA Recognition Motifs Participate in RNA Recognition and Structural Organization by the Pro-Apoptotic Factor TIA-1

William J. Bauer, Jason Heath, Jermaine L. Jenkins, Clara L. Kielkopf

Journal:

Journal of Molecular Biology

Année:

2012

Langue:

english

Fichier:

PDF, 1.91 MB

english, 2012

16

Structural Basis for Polypyrimidine Tract Recognition by the Essential Pre-mRNA Splicing Factor U2AF65

E. Allen Sickmier, Katherine E. Frato, Haihong Shen, Shanthi R. Paranawithana, Michael R. Green, Clara L. Kielkopf

Journal:

Année:

2006

Langue:

english

Fichier:

PDF, 796 KB

english, 2006

17

Structural Basis for NADH/NAD+ Redox Sensing by a Rex Family Repressor

Krystle J. McLaughlin, Claire M. Strain-Damerell, Kefang Xie, Dimitris Brekasis, Alexei S. Soares, Mark S.B. Paget, Clara L. Kielkopf

Journal:

Année:

2010

Langue:

english

Fichier:

PDF, 2.31 MB

english, 2010

18

A Novel Peptide Recognition Mode Revealed by the X-Ray Structure of a Core U2AF35/U2AF65 Heterodimer

Clara L. Kielkopf, Natalia A. Rodionova, Michael R. Green, Stephen K. Burley

Journal:

Année:

2001

Langue:

english

Fichier:

PDF, 598 KB

english, 2001

19

Structure of Phosphorylated SF1 Bound to U2AF65 in an Essential Splicing Factor Complex

Wang, Wenhua, Maucuer, Alexandre, Gupta, Ankit, Manceau, Valérie, Thickman, Karen R., Bauer, William J., Kennedy, Scott D., Wedekind, Joseph E., Green, Michael R., Kielkopf, Clara L.

Journal:

Année:

2013

Langue:

english

Fichier:

PDF, 2.23 MB

english, 2013

20

Thermodynamic Characteristics of pre-mRNA Splice Site Recognition

Williams, Krystle J., Jenkins, Jermaine L., Kielkopf, Clara L.

Journal:

Biophysical Journal

Année:

2009

Langue:

english

Fichier:

PDF, 50 KB

english, 2009

21

Staufen1 dimerizes through a conserved motif and a degenerate dsRNA-binding domain to promote mRNA decay

Gleghorn, Michael L, Gong, Chenguang, Kielkopf, Clara L, Maquat, Lynne E

Journal:

Nature Structural and Molecular Biology

Année:

2013

Langue:

english

Fichier:

PDF, 2.00 MB

english, 2013

22

A Novel Domain Implicated in the Interactions between pre-mRNA Splicing Factors

Gupta, Ankit, Kielkopf, Clara L.

Journal:

Biophysical Journal

Année:

2009

Langue:

english

Fichier:

PDF, 39 KB

english, 2009

23

Structural and Thermodynamic Means for Adaptable 3′ Splice Site Recognition

Kielkopf, Clara L.

Journal:

Biophysical Journal

Année:

2009

Langue:

english

Fichier:

PDF, 61 KB

english, 2009

24

X-ray Structures of Threonine Aldolase Complexes: Structural Basis of Substrate Recognition †,‡

Kielkopf, Clara L., Burley, Stephen K.

Journal:

Année:

2002

Langue:

english

Fichier:

PDF, 1022 KB

english, 2002

25

Large Favorable Enthalpy Changes Drive Specific RNA Recognition by RNA Recognition Motif Proteins

McLaughlin, Krystle J., Jenkins, Jermaine L., Kielkopf, Clara L.

Journal:

Année:

2011

Langue:

english

Fichier:

PDF, 1.44 MB

english, 2011

26

X-ray Structures of U2 snRNA−Branchpoint Duplexes Containing Conserved Pseudouridines †‡

Lin, Yuan, Kielkopf, Clara L.

Journal:

Année:

2008

Langue:

english

Fichier:

PDF, 9.13 MB

english, 2008

27

A Broad Range of Conformations Contribute to the Solution Ensemble of the Essential Splicing Factor U2AF 65

Jenkins, Jermaine L., Laird, Kholiswa M., Kielkopf, Clara L.

Journal:

Année:

2012

Langue:

english

Fichier:

PDF, 1.89 MB

english, 2012

28

Structure of a DNA Repair Substrate Containing an Alkyl Interstrand Cross-Link at 1.65 Å Resolution †,‡

Swenson, Matthew C., Paranawithana, Shanthi R., Miller, Paul S., Kielkopf, Clara L.

Journal:

Année:

2007

Langue:

english

Fichier:

PDF, 378 KB

english, 2007

29

Structure-guided U2AF 65 variant improves recognition and splicing of a defective pre-mRNA

Agrawal, Anant A., McLaughlin, Krystle J., Jenkins, Jermaine L., Kielkopf, Clara L.

Journal:

Proceedings of the National Academy of Sciences

Année:

2014

Langue:

english

Fichier:

PDF, 873 KB

english, 2014

30

Cancer-relevant Splicing Factor CAPERα Engages the Essential Splicing Factor SF3b155 in a Specific Ternary Complex

Loerch, Sarah, Maucuer, Alexandre, Manceau, Valérie, Green, Michael R., Kielkopf, Clara L.

Journal:

Journal of Biological Chemistry

Année:

2014

Langue:

english

Fichier:

PDF, 3.51 MB

english, 2014

31

Dividing and Conquering the Family of RNA Recognition Motifs: A Representative Case Based on hnRNP L

Loerch, Sarah, Kielkopf, Clara L.

Journal:

Journal of Molecular Biology

Année:

2015

Langue:

english

Fichier:

PDF, 337 KB

english, 2015

32

Unmasking the U2AF homology motif family: a bona fide protein–protein interaction motif in disguise

Loerch, Sarah, Kielkopf, Clara L.

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 842 KB

english, 2016

33

SF1 Phosphorylation Enhances Specific Binding to U2AF65 and Reduces Binding to 3′-Splice-Site RNA

Chatrikhi, Rakesh, Wang, Wenhua, Gupta, Ankit, Loerch, Sarah, Maucuer, Alexandre, Kielkopf, Clara L.

Journal:

Biophysical Journal

Année:

2016

Langue:

english

Fichier:

PDF, 2.83 MB

english, 2016

34

An extended U2AF65–RNA-binding domain recognizes the 3′ splice site signal

Agrawal, Anant A., Salsi, Enea, Chatrikhi, Rakesh, Henderson, Steven, Jenkins, Jermaine L., Green, Michael R., Ermolenko, Dmitri N., Kielkopf, Clara L.

Journal:

Nature Communications

Année:

2016

Langue:

english

Fichier:

PDF, 2.70 MB

english, 2016

35

Splicing Factor Mutations in Myelodysplasias: Insights from Spliceosome Structures

Jenkins, Jermaine L., Kielkopf, Clara L.

Journal:

Trends in Genetics

Année:

2017

Langue:

english

Fichier:

PDF, 2.76 MB

english, 2017

36

Cancer-Associated Mutations Mapped on High-Resolution Structures of the U2AF2 RNA Recognition Motifs

Glasser, Eliezra, Agrawal, Anant A., Jenkins, Jermaine L., Kielkopf, Clara L.

Journal:

Année:

2017

Langue:

english

Fichier:

PDF, 3.68 MB

english, 2017

37

Insights from structures of cancer-relevant pre-mRNA splicing factors

Kielkopf, Clara L

Journal:

Current Opinion in Genetics & Development

Année:

2018

Langue:

english

Fichier:

PDF, 1.58 MB

english, 2018

38

Wild-Type U2AF1 Antagonizes the Splicing Program Characteristic of U2AF1-Mutant Tumors and Is Required for Cell Survival

Fei, Dennis Liang, Motowski, Hayley, Chatrikhi, Rakesh, Prasad, Sameer, Yu, Jovian, Gao, Shaojian, Kielkopf, Clara L., Bradley, Robert K., Varmus, Harold, Grimes, H. Leighton

Journal:

Année:

2016

Langue:

english

Fichier:

PDF, 2.38 MB

english, 2016

39

The pre-mRNA splicing and transcription factor Tat-SF1 is a functional partner of the spliceosome SF3b1 subunit via a U2AF homology motif interface

Loerch, Sarah, Leach, Justin R, Horner, Steven W, Maji, Debanjana, Jenkins, Jermaine L, Pulvino, Mary, Kielkopf, Clara L.

Journal:

Journal of Biological Chemistry

Année:

2018

Langue:

english

Fichier:

PDF, 3.89 MB

english, 2018

40

Cus2 enforces the first ATP-dependent step of splicing by binding to yeast SF3b1 through a UHM-ULM interaction

Talkish, Jason, Igel, Haller, Hunter, Oarteze, Horner, Steven W, Jeffery, Nazish N, Leach, Justin R, Jenkins, Jermaine L, Kielkopf, Clara L, Ares, Manuel

Journal:

Année:

2019

Fichier:

PDF, 3.36 MB

2019

41

Structures of SF3b1 reveal a dynamic Achilles heel of spliceosome assembly: Implications for cancer-associated abnormalities and drug discovery

Maji, Debanjana, Grossfield, Alan M., Kielkopf, Clara L.

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

Année:

2019

Langue:

english

Fichier:

PDF, 6.68 MB

english, 2019

42

Structures of SF3b1 reveal a dynamic Achilles heel of spliceosome assembly: Implications for cancer-associated abnormalities and drug discovery

Maji, Debanjana, Grossfield, Alan M., Kielkopf, Clara L.

Journal:

Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms

Année:

2019

Fichier:

PDF, 6.68 MB

2019

43

A splice site-sensing conformational switch in U2AF2 is modulated by U2AF1 and its recurrent myelodysplasia-associated mutation

Warnasooriya, Chandani, Feeney, Callen F, Laird, Kholiswa M, Ermolenko, Dmitri N, Kielkopf, Clara L

Journal:

Nucleic Acids Research

Année:

2020

Fichier:

PDF, 5.06 MB

2020

44

Purification of Fusion Proteins by Affinity Chromatography on Glutathione Resin

Kielkopf, Clara L., Bauer, William, Urbatsch, Ina L.

Journal:

Cold Spring Harbor Protocols

Année:

2020

Fichier:

PDF, 379 KB

2020

45

Expression of Cloned Genes Using the Baculovirus Expression System

Kielkopf, Clara L., Bauer, William, Urbatsch, Ina L.

Journal:

Cold Spring Harbor Protocols

Année:

2020

Fichier:

PDF, 958 KB

2020

46

Representative cancer-associated U2AF2 mutations alter RNA interactions and splicing

Maji, Debanjana, Glasser, Eliezra, Henderson, Steven, Galardi, Justin, Pulvino, Mary J, Jenkins, Jermaine L., Kielkopf, Clara L.

Journal:

Journal of Biological Chemistry

Année:

2020

Fichier:

PDF, 3.72 MB

2020